Publications

1) Arai M, Kaku M, Thant L, Kitami M, Ono Y, Dobashi A, Iwama H, Mizukoshi M, Kitami K, Matsumoto M, Saito I, Uoshima K: Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells. Biochem Biophys Res Commun. 692:149364, 2024. doi: 10.1016/j.bbrc.2023.149364.

2) Kaku M, Thant L, Dobashi A, Ono Y, Kitami M, Mizukoshi M, Arai M, Iwama H, Kitami K, Kakihara Y, Matsumoto M, Saito I, Uoshima K: Multiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix. Sci Rep. 14(1):354, 2024. doi: 10.1038/s41598-023-51054-8.

3) Kantaputra P, Daroontum T, Kitiyamas K, Piyakhunakorn P, Kawasaki K, Sathienkijkanchai A, Wasant P, Vatanavicharn N, Yasanga T, Kaewgahya M, Tongsima S, Cox TC, Arold ST, Ohazama A, Ngamphiw C: Homozygosity for a rare plec variant suggests a contributory role in congenital insensitivity to pain. Int J Mol Sci. 25(12):6358, 2024. doi: 10.3390/ijms25126358.

4) Kawasaki M, Kawasaki K, Sari FT, Kudo T, Nihara J, Kitamura M, Nagai T, Utama V, Ishida Y, Meguro F, Kesuma A, Fujita A, Nishimura T, Kogure Y, Maruyama S, Tanuma J, Kakihara Y, Maeda T, Ghafoor S, Khonsari RH, Corre P, Sharpe PT, Cobourne M, Franco B, Ohazama A: Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling. Elife 13:e85042, 2024. doi: 10.7554/eLife.85042.

5) Kitami M, Kaku M, Thant L, Maeda T: A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage. Geroscience. 2024 Dec;46(6):5995-6007. doi: 10.1007/s11357-024-01143-x. Epub 2024 Mar 25.

6) Kiyokawa Y, Terajima M, Sato M, Inada E, Hori Y, Bando R, Iwase Y, Kubota N, Murakami T, Tsugane H, Watanabe S, Sonomura T, Terunuma M, Maeda T, Noguchi H, Saitoh I: Scratch-Based Isolation of Primary Cells (SCIP): A novel method to obtain a large number of human dental pulp cells through one-step cultivation. J Clin Med. 13(23):7058, 2024. doi: 10.3390/jcm13237058.

7) Nagoya K, Tsujimura T, Yoshihara M, Watanabe M, Magara J, Kawasaki K, Inoue M: Physiological analyses of swallowing changes due to chronic obstructive pulmonary disease in anesthetized male rats. Front Physiol. 15:1445336, 2024. doi: 10.3389/fphys.2024.1445336.

8) Ruangchan C, Ngamphiw C, Krasaesin A, Intarak N, Tongsima S, Kaewgahya M, Kawasaki K, Mahawong P, Paripurana K, Sookawat B, Jatooratthawichot P, Cox TC, Ohazama A, Ketudat Cairns JR, Porntaveetus T, Kantaputra P: Genetic variants in KCTD1 are associated with isolated dental anomalies. Int J Mol Sci. 25(10):5179, 2024. doi: 10.3390/ijms25105179.

9) Saito R, Domon H, Hiyoshi T, Hirayama S, Maekawa T, Takenaka S, Noiri Y, Ikeda A, Hirose T, Sunazuka T, Terao Y: A novel 12-membered ring non-antibiotic macrolide EM982 attenuates cytokine production by inhibiting IKKβ and IκBα phosphorylation. J Biol Chem. 300 (6): 107384, 2024.

10) Sirisereephap K, Surboyo MDC, Rosenkranz AL, Terao Y, Tabeta K, Maeda T, Hajishengallis G, Maekawa T: Protocols for collecting mouse PDL cells and bone marrow cells, differentiation, and data analysis. STAR Protoc. 5 (3): 103162, 2024.

11) Sirisereephap K, Tamura H, Lim JH, Surboyo MDC, Isono T, Hiyoshi T, Rosenkranz AL, Sato-Yamada Y, Domon H, Ikeda A, Hirose T, Sunazuka T, Yoshiba N, Okada H, Terao Y, Maeda T, Tabeta K, Chavakis T, Hajishengallis G, Maekawa T: A novel macrolide-Del-1 axis to regenerate bone in

12) old age. iSceince. 27 (2): 108798, 2024.

13) Ujita T, Yamamoto T, Sato-Yamada Y, Kishimoto N, Maeda T, Seo K: Optical Imaging of Trigeminal Ganglion Excitation Evoked by Electrical Stimulation of the Trigeminal Nerve. Cureus 16(12), 2024 :e75522. doi:10.7759/cureus.75522

14) Y Ono 1, M Kaku 1, L Thant 2 3 4, H Iwama 2, M Arai 2, M Mizukoshi 2, A Dobashi 2, M Kitami 3 4, M M Taketo 5, A Ohazama 6, I Saito 2, K Uoshima: Wnt/β-catenin Promotes Cementum Apposition in Periodontal Regeneration. J Dent Res. 220345241286490, 2024. doi: 10.1177/00220345241286490.

15) Yamada-Hara M, Takahashi N, Byun JW, Zeng L, Wang Z, Tanaka A, Malakoutikhah Z, Hayashi T, Webster NJG, Raz E, Bertin S: In Vivo Bioluminescence Imaging of Tumor Progression in the Lewis Lung Carcinoma Orthotopic Mouse Model – A Comparison Between the Tail Vein Injection and Intranasal Instillation Methods. Curr Protoc. 2024.

16) Yamaguchi H, Kitami M, Li M, Swaminathan S, Darabi R, Takemaru KI, Komatsu Y: Disruption of distal appendage protein CEP164 causes skeletal malformation in mice. Biochem Biophys Res Commun. 741:151063, 2024. doi: 10.1016/j.bbrc.2024.151063.

1) Sirisereephap K, Tamura H, Lim JH, Surboyo MDC, Isono T, Hiyoshi T, Rosenkranz AL, Sato-Yamada Y, Domon H, Ikeda A, Hirose T, Sunazuka T, Yoshiba N, Okada H, Terao Y, Maeda T, Tabeta K, Chavakis T, Hajishengallis G, Maekawa T: A novel macrolide-del-1 axis to regenerate bone in old age. iScience., 27(2):108798, 2024.

2) Yasui Y, Hirayama S, Hiyoshi T, Isono T, Domon H, Maekawa T, Tabeta K, Terao Y: The Pneumococcal Protein SufC Binds to Host Plasminogen and Promotes Its Conversion into Plasmin. Microorganisms., 11(12):2969, 2023.

3) Akimori T, Yamazaki M, Abé T, Maruyama S, Tomihara K, Maeda T, Tanuma J: Searching for early detection markers of oral epithelial dysplasia and oral squamous cell carcinoma using oral liquid-based cytology. J Oral Maxillofac Surg. Med., Pathol., Available online 25 November 2023.

4) Kudo T, Kawasaki M, Kawasaki K, Meguro F, Nihara J, Honda I, Kitamura M, Fujita A, Osawa K, Ichikawa K, Nagai T, Ishida Y, Sharpe PT, Maeda T, Saito I, Ohazama A.: Ift88 regulates enamel formation via involving Shh signaling. Oral Dis., 29(4):1622-1631, 2023.

5) Domon H, Hirayama S, Isono T, Sasagawa K, Takizawa F, Maekawa T, Yanagihara K, Terao Y: Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae. Microbiol Spectr., 11(3):e0014823, 2023.

6) Isono T, Hirayama S, Domon H, Maekawa T, Tamura H, Hiyoshi T, Sirisereephap K, Takenaka S, Noiri Y, Terao Y: Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia. J Biol Chem., 299(6):104760, 2023.

7) Takizawa F, Domon H, Hiyoshi T, Tamura H, Shimizu K, Maekawa T, Tabeta K, Ushida A, Terao Y: Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLoS One, 18(4):e0284115, 2023.

8) Hirayama S, Hiyoshi T, Yasui Y, Domon H, Terao Y.; C-terminal lysine residue of pneumococcal triosephosphate isomerase contributes to its binding to host plasminogen. Microorganisms, 11(5) 1198, 2023.

9) Sato-Yamada Y, Strickland A, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J: A SARM1/mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model. J Clin Invest., 132(23): e161566, 2022.

10) Dingwall CB, Strickland A, Yum SW, Yim A K-Y, Zhu J, Wang PL, Yamada Y, Schmidt RE, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J: Macrophage depletion blocks congenital SARM1-dependent neuropathy. J Clin Invest., 132(23): e159800, 2022.

11) Tamura H, Maekawa T, Domon H, Sirisereephap K, Isono T, Hirayama S, Hiyoshi T, Sasagawa K, Takizawa F, Maeda T, Terao Y, Tabeta K.: Erythromycin Restores Osteoblast Differentiation and Osteogenesis Suppressed by Porphyromonas gingivalis Lipopolysaccharide. Pharmaceuticals (Basel), 16(2):303, 2023.

12) Zeng L, Herdman DS, Lee SM, Tao A, Das M, Bertin S, Eckmann L, Mahata SK, Wu P, Hara M, Byun JW, Devulapalli S, Patel HH, Molina AJA, Osborn O, Corr M, Raz E, Webster NJG. Loss of cAMP Signaling in CD11c Immune Cells Protects Against Diet-Induced Obesity. Diabetes, 72(9):1235-1250，2023．

13) Yamaguchi H, Li M, Kitami M, Swaminathan S, Mishina Y, Komatsu Y.: Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification. Biochem Biophys Res Commun. 688:149147, 2023.

14) Asami E, Kitami M, Ida T, Kobayashi T, Saeki M.: Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1. Immunopharmacol Immunotoxicol. 45(5):589-596, 2023.

15) Kitami M, Kaku M, Thant L, Maeda T. A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage. Geroscience. 2024 Mar 25. doi: 10.1007/s11357-024-01143-x. Online ahead of print.

16) Kantaputra P, Leelaadisorn N, Hatsadaloi A, Quarto N, Intachai W, Tongsima S, Kawasaki K, Ohazama A, Ngamphiw C, Wiriyakijja P. A Mutation in CACNA1S Is Associated with Multiple Supernumerary Cusps and Root Maldevelopment. Diagnostics (Basel). 13(5):895, 2023.

17) Kantaputra P, Butali A, Eliason S, Chalkley C, Nakornchai S, Bongkochwilawan C, Kawasaki K, Kumchiang A, Ngamphiw C, Tongsima S, Ketudat Cairns JR, Olsen B, Intachai W, Ohazama A, Tucker AS, Amendt BA. CACNA1S mutation-associated dental anomalies: A calcium channelopathy. Oral Dis. 2023 Feb 24. doi: 10.1111/odi.14551. Online ahead of print.

1) Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A: Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell reports 39(13):111001-111001, 2022.

2) Sato-Yamada Y, Strickland A, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J: A SARM1/mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model. J Clin Invest. in press.

3) Dingwall CB, Strickland A, Yum SW, Yim A K-Y, Zhu J, Wang PL, Yamada Y, Schmidt RE, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J: Macrophage depletion blocks congenital SARM1-dependent neuropathy. J Clin Invest. in press.

4) Yamazaki K, Miyauchi E, Kato T, Sato K, Suda W, Tsuzuno T, Yamada-Hara M, Sasaki N, Ohno H, Yamazaki K, Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice J Oral Microbiol. 14(1):2110194, 2022.

5) Kudo T, Kawasaki M, Kawasaki K, Meguro F, Nihara J, Honda I, Kitamura M, Fujita A, Osawa K, Ichikawa K, Nagai T, Ishida Y, Sharpe PT, Maeda T, Saito I, Ohazama A.: Ift88 regulates enamel formation via involving Shh signaling. Oral Dis. 2022 in press

6) Hirayama S, Domon H, Hiyoshi T, Isono T, Tamura H, Sasagawa K, Takizawa F, Terao Y.: Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. FEBS Open Bio. 12(6): 1206-1219, 2022.

7) Sirisereephap K, Maekawa T, Tamura H, Hiyoshi T, Domon H, Isono T, Terao Y, Maeda T, Tabeta K.: Osteoimmunology in periodontitis: Local proteins and compounds to alleviate periodontitis. Int J Mol Sci. 23(10): 5540, 2022.

8) Hiyoshi, T, Domon, H, Maekawa, T, Tamura, H, Isono, T, Hirayama, S, Sasagawa, K, Takizawa, F, Tabeta, K, Terao, Y.: Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules. Sci Rep. 12: 8159, 2022

9) Lwin HY, Aoki-Nonaka Y, Matsugishi A, Takahashi N, Hiyoshi T, Tabeta K: Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity. Arch Oral Biol. 105497, 2022.

10) Komatsu A, Iida I, Nasu Y, Ito G, Harada F, Kishikawa S, Moss SJ, Maeda T, Terunuma M: Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum. J Biol Chem. 298(5): 101933, 2022.

11) Thant L, Kaku M, Kakihara Y, Mizukoshi M, Kitami M, Arai M, Kitami K, Kobayashi D, Yoshida Y, Maeda T, Saito I, Uoshima K, Saeki M. Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress. Front Physiol. 20(13):899699, 2022.

12) Thant L, Kakihara Y, Kaku M, Kitami M, Kitami K, Mizukoshi M, Maeda T, Saito I, Saeki M. Involvement of Rab11 in osteoblastic differentiation: Its up-regulation during the differentiation and by tensile stress. Biochem Biophys Res Commun. 624:16-22, 2022.

13) Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y. Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 482:91-100, 2022.

1) Nogami Y, Saitoh I, Inada E, Murakami D, Iwase Y, Kubota N, Nakamura Y, Nakakura-Ohshima K, Suzuki A, Yamasaki Y, Hayasaki H, Kaihara Y: Lip-closing strength in children is enhanced by lip and facial muscle training. Clin. Exp. Dent. Res., 2021 in press.

2) Sasagawa K, Domon H, Sakagami R, Hirayama S, Maekawa T, Isono T, Hiyoshi T, Tamura H, Takizawa F, Fukushima Y, Tabeta K, Terao Y: Matcha green tea exhibits bactericidal activity against Streptococcus pneumoniae and inhibits functional pneumolysin. Antibiotics (Basel), 10(12): 1550, 2021.

3) Yamada Y, Nihara J, Trakanant S, Kudo T, Seo K, Iida I, Izumi K, Kurose M, Shimomura Y, Terunuma M, Maeda T, Ohazama A: Perivascular Hedgehog responsive cells play a critical role in peripheral nerve regeneration via controlling angiogenesis. Neurosci. Res., 173: 62-70, 2021.

4) Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y: Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol., 482: 91-100, 2021.

5) Yoshiba N, Edanami N, Ohkura N, Maekawa T, Takahashi N, Tsuzuno T, Maeda T, Tabeta K, Izumi K, Noiri Y, Yoshiba K: Laminin isoforms in human dental pulp: lymphatic vessels express laminin-332, and Schwann cell-associated laminin-211 modulates CD163 expression of M2-like macrophages. Immunohorizons, 5(12): 1008-1020, 2021.

6) Kantaputra PN, Dejkhamron P, Intachai W, Ngamphiw C, Ketudat Cairns JR, Kawasaki K, Ohazama A, Olsen B, Tongsima S, Angkurawaranon S: A novel P3H1 mutation is associated with osteogenesis imperfecta type VIII and dental anomalies. Oral Surg Oral Med Oral Pathol Oral Radiol., 132(6): e198-e207, 2021.

7) Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI: Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression. Transl. Oncol., 14(12): 1012362021, 2021.

8) Domon H, Isono T, Hiyoshi T, Tamura H, Sasagawa K, Maekawa T, Hirayama S, Yanagihara K, Terao Y: Clarithromycin inhibits pneumolysin production via downregulation of ply gene transcription despite autolysis activation. Microbiol. Spectr., 9(2): e00318-21, 2021.

9) Naksagoon T, Takenaka S, Nagata R, Sotozono M, Ohsumi T, Ida T, Edanami N, Maeda T, Noiri Y: A repeated state of acidification enhances the anticariogenic biofilm activity of glass ionomer cement containing fluoro-zinc-silicate fillers. Antibiotics (Basel), 10(8): 977, 2021.

10) Nihara J, Kawasaki M, Kawasaki K, Yamada A, Meguro F, Kudo T, Trakanant S, Nagai T, Saito I, Maeda T, Ohazama A: Expression of R-spondins/Lgrs in development of movable craniofacial organs. Gene Expr. Patterns, 41:119195, 2021.

11) Mineo S, Takahashi N, Yamada-Hara M, Tsuzuno T, Aoki-Nonaka Y, Tabeta K: Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells. Arch. Oral Biol., 129: 105215, 2021.

12) Hoshikawa E, Sato T, Haga K, Suzuki A, Kobayashi R, Tabeta K, Izumi K: Cells/colony motion of oral keratinocytes determined by non-invasive and quantitative measurement using optical flow predicts epithelial regenerative capacity Sci. Rep., 11(1):10403, 2021.

13) Yamazaki M, Tsurumaki T, Yamada Y, Maeda T, Seo K: Rapid elevation of BDNF production in the bilateral trigeminal ganglia by unilateral transection of the mental nerve in mice. Neuroreport, 32(8): 659-665, 2021.

14) Tsuzuno T, Takahashi N, Yamada-Hara M, Yokoji-Takeuchi M, Sulijaya B, Aoki-Nonaka Y, Matsugishi A, Katakura K, Tabeta K, Yamazaki K: Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice. J. Periodontal Res., 56(2): 275-288, 2021.

15) Sato K, Yamazaki K, Kato T, Nakanishi Y, Tsuzuno T, Yokoji-Takeuchi M, Yamada-Hara M, Miura N, Okuda S, Ohno H, Yamazaki K: Obesity-related gut microbiota aggravates alveolar bone destruction in experimental periodontitis through elevation of uric acid. mBio, 12(3): e0077121, 2021.

16) Tamura H, Maekawa T, Domon H, Hiyoshi T, Hirayama S, Isono T, Sasagawa K, Yonezawa D, Takahashi N, Oda M, Maeda T, Tabeta K, Terao Y: Effects of erythromycin on osteoclasts and bone resorption via DEL-1 induction in mice. Antibiotics(Basel), 10(3): 312, 2021.

17) Kantaputra PN, Dejkhamron P, Intachai W, Ngamphiw C, Kawasaki K, Ohazama A, Krisanaprakornkit S, Tongsima S, Ketudat Cairns JR: Juberg-Hayward syndrome is a cohesinopathy, caused by mutations in ESCO2. Eur. J. Orthod., 43: 45-50, 2021.

18) Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M: A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background. Behav. Brain Res., 405: 113194, 2021.

19) Matsugishi A, Aoki-Nonaka Y, Yokoji-Takeuchi M, Yamada-Hara M, Mikami Y, Hayatsu M, Terao Y, Domon H, Taniguchi M, Takahashi N, Yamazaki K, Tabeta K: Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum. Arch. Oral Biol., 121: 104956, 2021.

20) Domon H, Maekawa T, Isono T, Furuta K, Kaito C, Terao Y: Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia. Sci. Rep., 11(1):2432, 2021.

21) Trakanant S, Nihara J, Nagai T, Kawasaki M, Kawasaki K, Ishida Y, Meguro F, Kudo T, Yamada A, Maeda T, Saito I, Ohazama A: MicroRNAs regulate distal region of mandibular development through Hh signaling. J. Anat., 238(3): 711-719, 2021.

22) Yang J, Kitami M, Pan H, Toda Nakamura M, Zhang H, Liu F, Zhu L, Komatsu Y, Mishina Y: Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate through suppressing autophagic β-catenin degradation. Sci. Signal., 14(665): eaaz9368, 2021.

23) Tamura H, Maekawa T, Hiyoshi T, Terao Y: Analysis of experimental ligature-induced periodontitis model in mice. Methods Mol. Biol., 2210: 237-250. 2021.

24) Naksagoon T, Ohsumi T, Takenaka S, Nagata R, Hasegawa T, Maeda T, Noiri Y: Effect of water aging on the anti-biofilm properties of glass ionomer cement containing fluoro-zinc-silicate fillers. Biofouling 36(9): 1090-1099, 2020.

25) 北見恩美：咬合高径の低下に対し治療用義歯を用いて咬合再構成を行った症例．日補綴歯会誌，13(2): 150-153, 2021.

1) Matsugishi A, Aoki-Nonaka Y, Yokoji-Takeuchi M, Yamada-Hara M, Mikami Y, Hayatsu M, Terao Y, Domon H, Taniguchi M, Takahashi N, Yamazaki K, Tabeta K: Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum. Arch. Oral Biol., 2020 in press.

2) Trakanant S, Nihara J, Nagai T, Kawasaki M, Kawasaki K, Ishida Y, Meguro F, Kudo T, Yamada A, Maeda T, Saito I, Ohazama A: MicroRNAs regulate distal region of mandibular development through Hh signaling. J. Anat., 2020 in press.

3) Yang J, Kitami M, Pan H, Toda Nakamura M, Zhang FH, Liu, Zhu L, Komatsu Y, Mishina Y: Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate through suppressing autophagic β-catenin degradation. Sci. Signal., 2020 in press.

4) Yamaguchi H, Terajima M, Kitami M, Wang J, He L, Saeki M, Yamauchi M, Komatsu Y: IFT20 is critical for collagen biosynthesis in craniofacial bone formation. Biochem. Biophys. Res. Commun., 2020 in press.

5) Kantaputra PN, Dejkhamron P, Intachai W, Ngamphiw C, Kawasaki K, Ohazama A, Krisanaprakornkit S, Tongsima S, Ketudat Cairns JR: Juberg-Hayward syndrome is a cohesinopathy, caused by mutations in ESCO2. Eur. J. Orthod., 2020 in press.

6) Tamura H, Maekawa T, Hiyoshi T, Terao Y: Analysis of experimental ligature-induced periodontitis model in mice. Methods Mol. Biol., 2020 in press.

7) Yamada A, Kawasaki M, Miake Y, Yamada Y, Blackburn J, Kawasaki K, Trakanant S, Nagai T, Nihara J, Kudo T, Meguro F, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Maeda T, Takagi R, Ohazama A: Overactivation of the NF-κB pathway impairs molar enamel formation. Oral Dis., 26(7): 1513-1522, 2020.

8) Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain I, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H: Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia. Glia, 68(11): 2330-2344, 2020.

9) Isono T, Domon H, Nagai K, Maekawa T, Tamura H, Hiyoshi T, Yanagihara K, Kunitomo E, Takenaka S, Noiri Y, Terao Y: Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model. PLoS One, 15(10): e0240329, 2020.

10) Yamada A, Nagai T, Kitamura A, Kawasaki M, Kawasaki K, Kodama Y, Maeda T, Ohazama A, Takagi R: Changes in signaling pathways in the palatal cleft in CL/Fr mice. J. Oral Maxillofac. Surg. Med. Pathol., 32(5): 331-335, 2020.

11) Kiyokawa Y, Sato M, Noguchi H, Inada E, Iwase Y, Kubota N, Sawami T, Terunuma M, Maeda T, Hayasaki H, Saitoh I: Drug-induced naïve iPS cells exhibit better performance than primed iPS cells with respect to the ability to differentiate into pancreatic β-cell lineage. J. Clin. Med., 9(9): E2838, 2020.

12) Maekawa T, Tamura H, Domon H, Hiyoshi T, Isono T, Yonezawa D, Hayashi N, Takahashi N, Tabeta K, Maeda T, Oda M, Ziogas A, Alexaki VΙ, Chavakis T, Terao Y, Hajishengallis G: Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1. JCI Insight, 5 (15): 136706, 2020.

13) Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Ohsumi T, Maekawa T, Yamasaki N, Furue Y, Terao Y: Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. Microbiol. Immunol., 64(7): 493-501. 2020.

14) Kantaputra P, Pruksachatkunakorn C, Intachai W, Ohazama A, Carlson Br, Kawasaki K, Chuamanochan, M: Clouston syndrome with pili canaliculi, pili torti, overgrown hyponychium, onycholysis, taurodontism, and absence of palmoplantar keratoderma. J. Dermatol., 47(6): e230-e232, 2020.

15) Soda M, Saito K, Ida-Yonemochi H, Nakakura-Ohshima K, Kenmotsu S, Ohshima H: Reduced enamel epithelium-derived cell niche in the junctional epithelium is maintained for a long time in mice. J. Periodontol., 91(6): 819-827, 2020.

16) Yuh DY, Maekawa T, Li X, Kajikawa T, Bdeir K, Chavakis T, Hajishengallis G: The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. J. Biol. Chem., 295(21): 7261-7273, 2020.

17) Yamada Y, Trakanant S, Nihara J, Kudo T, Seo K, Saeki M, Kurose M, Matsumaru D, Maeda T, Ohazama A: Gli3 is a key factor in the Schwann cells from both intact and injured peripheral nerves. Neuroscience, 432: 229-239, 2020.

18) Hiyoshi T, Domon H, Maekawa T, Yonezawa D, Kunitomo E, Tabeta K, Terao Y: Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice. Arch. Oral Biol., 112: 104679, 2020.

19) Yoshiba N, Edanami N, Ohkura N, Maekawa T, Takahashi N, Tohma A, Izumi K, Maeda T, Hosoya A, Nakamura H, Tabeta K, Noiri Y, Yoshiba K: M2 phenotype macrophages colocalize with Schwann cells in human dental pulp. J. Dent. Res., 99(3): 329-338, 2020.

20) Ziogas A, Maekawa T, Wiessner JR, Le TT, Sprott D, Troullinaki M, Neuwirth A, Anastasopoulou V, Grossklaus S, Chung KJ, Sperandio M, Chavakis T, Hajishengallis G, Alexaki VI: DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist DEL-1. J Immunol., 204(5): 1214-1224, 2020.

21) Kitamura A, Kawasaki M, Kawasaki K, Meguro F, Yamada A, Nagai T, Kodama Y, Trakanant S, Sharpe PT, Maeda T, Takagi R, Ohazama A: Ift88 is involved in mandibular development. J. Anat., 236(2): 317-324. 2020.

22) Hasegawa T, Takenaka S, Ohsumi T, Ida T, Ohshima H, Terao Y, Naksagoon T, Maeda T, Noiri Y: Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin. Oral Invest., 24(2): 963-970, 2020.

23) Yokoji-Takeuchi M, Takahashi N, Yamada-Hara M, Sulijaya B, Tsuzuno T, Aoki-Nonaka Y, Tabeta K, Kishino S, Ogawa J, Yamazaki K: A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway. Arch. Oral Biol., 110: 104602, 2020.

24) Herath C, Nandasena T, Thwin KM, Abeysundara A, Ratnayake S, Ogawa H, Miyazaki H, Maeda T: Effectiveness of school-based fluoride mouth rinsing program in schoolchildren from Kandy District, Sri Lanka. Stoma. Edu. J., 7(1): 7-14, 2020.

25) 北見恩美：咬合高径の低下に対し治療用義歯を用いて咬合再構成を行った症例．日補綴歯会誌，2020 印刷中．

26) 伊藤加代子，前川知樹，濃野 要，井上 誠：舌ブラシ先端形状による細菌除去および洗浄後のブラシの残留細菌数の違い．日摂食嚥下リハ会誌 24(2): 170-176, 2020.

27) 加来咲子, 野代悦生, 矢鳴耕太郎：加圧形成器で作製した EN リテーナーの改良（第２報）．九矯歯誌，15(1): 9-13, 2020.

28) 野代悦生, 加来咲子, 川元龍夫：ウサギの歯を実験的に種々に削合した時の咬合平面の推移について．九矯歯誌，15(1): 20-29, 2020.

1) Yamada A, Nagai T, Kitamura A, Kawasaki M, Kawasaki K, Kodama Y, Maeda T, Ohazama A, Takagi R: Changes in signaling pathways in the palatal cleft in CL/Fr mice. J. Oral Maxillofac. Surg. Med. Pathol., 2019 in press.

2) Yoshiba N, Edanami N, Ohkura N, Maekawa T, Takahashi N, Tohma A, Izumi K, Maeda T, Hosoya A, Nakamura H, Tabeta Koichi, Noiri Y, Yoshiba K: M2 phenotype macrophages colocalize with Schwann cells in human dental pulp. J. Dent. Res., 2019 in press.

3) Yokoji-Takeuchi M, Takahashi N, Yamada-Hara M, Sulijaya B, Tsuzuno T, Aoki-Nonaka Y, Tabeta K, Kishino S, Ogawa J, Yamazaki K: A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway. Arch. Oral Biol., 2019 in press.

4) Kitamura A, Kawasaki M, Kawasaki K, Meguro F, Yamada A, Nagai T, Kodama Y, Trakanant S, Sharpe PT, Maeda T, Takagi R, Ohazama A: Ift88 is involved in mandibular development. J. Anat., 2019 in press.

5) Hasegawa T, Takenaka S, Ohsumi T, Ida T, Ohshima H, Terao Y, Naksagoon T, Maeda T, Noiri Y: Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin. Oral Invest., 2019 in press.

6) Sulijaya B, Yamada-Hara M, Yokoji-Takeuchi M, Matsuda-Matsukawa Y, Yamazaki K, Matsugishi A, Tsuzuno T, Sato K, Aoki-Nonaka Y, Takahashi N, Kishino S, Ogawa J, Tabeta K, Yamazaki K: Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis. J. Periodontol., 90(12): 1470-1480, 2019.

7) Nakaniwa M, Kawasaki M, Kawasaki K, Yamada A, Meguro F, Maeda T, Ohazama A: Primary cilia in murine palatal rugae development. Gene Expr. Patterns, 34: 119062, 2019.

8) Hasegawa T, Miyamoto-Takasaki Y, Abe M, Qiu Z, Yamamoto T, Yoshida T, Yoshino H, Hongo H, Yokoyama A, Sasaki M, Kuroshima S, Hara K, Kobayashi M, Akiyama Y, Maeda T, Luiz de Freitas PH, Li M, Amizuka N: Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats. Microscopy (Oxf), 68(5): 349-358, 2019.

9) Takahashi N, Sulijaya B, Yamada-Hara M, Tsuzuno T, Tabeta K, Yamazaki K: Gingival epithelial barrier: regulation by beneficial and harmful microbes. Tissue Barriers, 7(3): e1651158, 2019.

10) Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y: Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways. Microbiol. Immunol., 63(6): 213-222, 2019.

11) Meguro F, Porntaveetus T, Kawasaki M, Kawasaki K, Yamada A, Kakihara Y, Saeki M, Tabeta K, Kessler JA, Maeda T, Ohazama A: Bmp signaling in molar cusp formation. Gene Expr. Patterns, 32: 67-71, 2019.

12) Tsujimura T, Ueha R, Yoshihara M, Takei E, Nagoya K, Shiraishi N, Magara J, Inoue M: Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats. J. Physiol., 597(11): 2949-2963, 2019.

13) Ashiga H, Takei E, Magara J, Takeishi R, Tsujimura T, Nagoya K, Inoue M: Effect of attention on chewing and swallowing behaviors in healthy humans. Sci. Rep., 9(1): 6013, 2019.

14) Kanemaru H, Tsurumaki T, Kurata S, Tanaka Y, Yoshikawa H, Sato Y, Kodama Y, Suda A, Yamada Y, Seo K: Endotracheal intubation complicated by a palatal tooth in a patient with Treacher Collins syndrome. Anesth. Prog., 66(1): 42-43, 2019.

15) Hiyoshi T, Domon H, Maekawa T, Nagai K, Tamura H, Takahashi N, Yonezawa D, Miyoshi T, Yoshida A, Tabeta K, Terao Y: Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. Microbiol. Immunol., 63(3-4): 100-110, 2019.

16) Kantaputra PN, Pruksametanan A, Phondee N, Hutsadaloi A, Intachai W, Kawasaki K, Ohazama A, Ngamphiw C, Tongsima S, Ketudat Cairns JR, Tripuwabhrut P: ADAMTSL1 and mandibular prognathism. Clin. Genet., 95(4): 507-515, 2019.

17) Watanabe M, Kawasaki M, Kawasaki K, Kitamura A, Nagai T, Kodama Y, Meguro F, Yamada A, Sharpe PT, Maeda T, Takagi R, Ohazama A: Ift88 limits bone formation in maxillary process through suppressing apoptosis. Arch. Oral Biol., 101:43-50, 2019.

18) Kanemaru H, Yamada Y, Ohazama A, Maeda T, Seo K: Semaphorin 3A inhibits nerve regeneration during early stages after inferior alveolar nerve transection. Sci. Rep., 9(1): 4245, 2019.

19) Nagai T, Trakanant S, Kawasaki M, Kawasaki K, Yamada Y, Watanabe M, Blackburn J, Otsuka-Tanaka Y, Hishinuma M, Kitamura A, Meguro F, Yamada A, Kodama Y, Maeda T, Zhou Q, Saijo Y, Yasue A, Sharpe PT, Hindges R, Takagi R, Ohazama A: MicroRNAs control eyelid development through regulating Wnt signaling. Dev. Dyn., 248(3): 201-210, 2019.

20) Nagai K, Domon H, Maekawa T, Hiyoshi T, Tamura H, Yonezawa D, Habuka R, Saitoh A, Terao Y: Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection. Vaccine, 37(1): 160-168, 2019.

21) Nagai K, Kimura O, Domon H, Maekawa T, Yonezawa D, Terao Y: Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J. Infect. Chemother., 25(3): 229-232, 2019.

22) Kitami M, Yamaguchi H, Ebina M, Kaku M, Chen D, Komatsu Y: IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage. Biochem. Biophys. Res. Commun., 509(1): 222-226, 2019.

23) Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Ochiai A, Taniguchi M, Tabeta K, Maeda T, Terao Y: Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. Arch. Oral Biol., 98: 132-139, 2019.

24) Nakajima M, Hosojima M, Tabeta K, Miyauchi S, Yamada-Hara M, Takahashi N, Miyazawa H, Matsuda-Matsukawa Y, Sato K, Sugita N, Komatsu Y, Ishikawa T, Akiishi K, Yamazaki K, Kato K, Saito A, Yoshie H: β2-microglobulin and neutrophil gelatinase-associated lipocalin, potential novel urine biomarkers in periodontitis: A cross-sectional study in Japanese. Int. J. Dent., 2019: 1394678, 2019.

25) Yokoji-Takeuchi M, Tabeta K, Takahashi N, Arimatsu K, Miyazawa H, Matsuda-Matsukawa Y, Sato K, Yamada M, Yamazaki K: Corrigendum to "Indirect regulation of PCSK9 gene in inflammatory response by Porphyromonas gingivalis infection". Heliyon 5(2): e01210, 2019.

26) Yokoji-Takeuchi M, Tabeta K, Takahashi N, Arimatsu K, Miyazawa H, Matsuda-Matsukawa Y, Sato K, Yamada M, Yamazaki K: Indirect regulation of PCSK9 gene in inflammatory response by Porphyromonas gingivalis infection. Heliyon, 5(1): e01111, 2019.

27) 加来咲子, 野代悦生, 矢鳴耕太郎：加圧形成器で作製した EN リテーナーの改良（第２報）．九矯歯誌 2019 印刷中．

28) 野代悦生, 加来咲子, 川元龍夫：ウサギの歯を実験的に種々に削合した時の咬合平面の推移について．九矯歯誌，2019 印刷中．

1) Hasegawa T, Miyamoto Y, Abe M, Qiu Z, Yamamoto T, Yimin Y, Yoshida T, Yoshino H, Hongo H, Yokoyama A, Moritani Y, Kirikoshi S, Morimoto Y, Sasaki M, Kuroshima S, Hara K, Kobayashi M, Akiyama Y, Maeda T, Luiz de Freitas PH, Li M, Amizuka N: Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats. J. Mol. Histol., 2018 submitted.

2) Hasegawa T, Takenaka S, Ohsumi T, Ida, T, Ohshima H, Terao Y, Traithawit N, Maeda T, Noiri Y: Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin. Oral Invest., 2018 submitted.

3) Kanemaru H, Yamada Y, Ohazama A, Maeda T, Seo K: Semaphorin 3A inhibits nerve regeneration during early stages after inferior alveolar nerve transection. Sci. Rep., 2018 in press.

4) Nagai K, Domon H, Maekawa T, Hiyoshi T, Tamura H, Yonezawa D, Habuka R, Saitoh A, Terao Y: Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection. Vaccine, 2018 in press.

5) Nagai K, Kimura O, Domon H, Maekawa T, Yonezawa D, Terao Y: Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J. Infect. Chemother., 2018 in press.

6) Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Ochiai A, Taniguchi M, Tabeta K, Maeda T, Terao Y: Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. Arch. Oral Biol., 2018 in press.

7) Rosales Rocabado JM, Kaku M, Nozaki K, Ida T, Kitami M, Aoyagi Y, Uoshima K: A multi-factorial analysis of bone morphology and fracture strength of rat femur in response to ovariectomy. J. Orthop. Surg. Res., 13(1): 318, 2018.

8) Ishikawa R, Kawasaki M, Kawasaki K, Yamada A, Trakanant S, Meguro F, Kitamura A, Kudo T, Maeda T, Ohazama A: Sox genes show spatiotemporal expression during murine tongue and eyelid development. Int. J. Dent., 2018: 1601363, 2018.

9) Nishida Y, Yamada Y, Kanemaru H, Ohazama A, Maeda T, Seo K: Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve regeneration., Biomed. Res., 39(6): 287-294, 2018.

10) Bostanci N, Bao K, Li X, Maekawa T, Grossmann J, Panse C, Briones RA, Resuello RRG, Tuplano JV, Garcia CAG, Reis ES, Lambris JD, Hajishengallis G: Gingival exudatome dynamics implicate inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis. J. Proteome Res., 17(9): 3153-3175, 2018.

11) Sulijaya B, Takahashi N, Yamada M, Yokoji M, Sato K, Aoki-Nonaka Y, Nakajima T, Kishino S, Ogawa J, Yamazaki K: The anti-inflammatory effect of 10-oxo-trans-11-octadecenoic acid (KetoC) on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide. J. Periodontal Res., 53(5): 777-784, 2018.

12) Kawasaki M, Kawasaki K, Meguro F, Yamada A, Ishikawa R, Porntaveetus T, Blackburn J, Otsuka-Tanaka Y, Saito N, Ota MS, Sharpe PT, Kessler JA, Herz J, Cobourne MT, Maeda T, Ohazama A: Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms. PLoS One, 13(9): e0204126, 2018.

13) Domon H, Maekawa T, Yonezawa D, Nagai K, Oda M, Yanagihara K, Terao Y: Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother., 62(11): e00161-18, 2018.

14) Oka H, Ishida Y, Hong G: Study of factors related to the attitudes toward studying abroad among preclinical/clinical undergraduate dental students at three dental schools in Japan. Clin. Exp. Dent. Res., 4(4): 119-124, 2018.

15) Ida T, Kaku M, Kitami M, Terajima M, Rosales Rocabado JM, Akiba Y, Nagasawa M, Yamauchi M, Uoshima K: Extracellular matrix with defective collagen cross-linking affects the differentiation of bone cells. PLoS One, 13(9): e0204306, 2018.

16) Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y: BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet., 14(5): e1007340, 2018.

17) Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y: Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia. Front. Immunol., 9: 732, 2018.

18) Yamada M, Takahashi N, Matsuda Y, Sato K, Yokoji M, Sulijaya B, Maekawa T, Ushiki T, Mikami Y, Hayatsu M, Mizutani Y, Kishino S, Ogawa J, Arita M, Tabeta K, Maeda T, Yamazaki K: A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling. Sci. Rep., 8(1): 9008, 2018.

19) Oda M, Kurosawa M, Yamamoto H, Domon H, Kimura T, Isono T, Maekawa T, Hayashi N, Yamada N, Furue Y, Kai D, Terao Y: Sulfated vizantin induces the formation of macrophage extracellular traps. Microbiol. Immunol., 62(5): 310-316, 2018.

20) Tabeta K, Hosojima M, Nakajima M, Miyauchi S, Miyazawa H, Takahashi N, Matsuda Y, Sugita N, Komatsu Y, Sato K, Ishikawa T, Akiishi K, Yamazaki K, Kato K, Saito A, Yoshie H: Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey. J. Periodontal. Res., 53(3): 446-456, 2018.

21) Porntaveetus T, Abid MF, Theerapanon T, Srichomthong C, Ohazama A, Kawasaki K, Kawasaki M, Suphapeetiporn K, Sharpe PT, Shotelersuk V: Expanding the oro-dental and mutational spectra of Kabuki syndrome and expression of KMT2D and KDM6A in human tooth germs. Int. J. Biol. Sci., 14(4): 381-389, 2018.

22) Yamada Y, Ohazama A, Maeda T, Seo K: The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration. Neurosci. Lett., 671: 114-119, 2018.

23) Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y: Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol., 325: 14-22, 2018.

24) Saito N, Kato H, Akiba Y, Hara Y, Kojima T, Yoshizawa M, Ohazama A, Maeda T, Kobayashi T, Izumi K: Application of hypoxic exposure combined with osteogenic induction for the enhancement of multiple osteoinductive capabilities in rat mesenchymal cells. Open Journal of Stomatology, 8: 53-69, 2018.

25) 塩見 晶, 石崎裕子, 伊藤晴江, 奥村暢旦, 長谷川真奈, 藤井規孝, 小林正治, 小野和宏, 前田健康：新潟大学歯学部における診療参加型臨床実習と歯科医師臨床研修の年間診療数に対する実態調査．日本歯科医学教育学会雑誌：34(3): 92-99, 2018.

26) 金丸博子, 弦巻 立, 倉田行伸, 田中 裕, 吉川博之, 佐藤由美子, 小玉由記, 須田有紀子, 山田友里恵, 瀬尾憲司：口蓋の転位歯が挿管操作を困難にした Treacher-Collins 症候群患者の１例．日歯麻誌，46(2): 89-91, 2018.

1) Yamada Y, Ohazama A, Maeda T, Seo K: The sonic hedgehog signaling pathway regulates inferior alveolar nerve regeneration. Neurosci. Lett., 2017 in press.

2) Kantaputra PN, Kapoor S, Verma P, Kaewgahya M, Kawasaki K, Ohazama A, Ketudat Cairns JR: Al-Awadi-Raas-Rothschild syndrome with dental anomalies and a novel WNT7A mutation. Eur. J. Med. Genet., 60: 695-700, 2017.

3) Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B: An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue. Sci. Rep., 7(1): 11717, 2017.

4) Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T: Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J. Clin. Invest., 127(10): 3624-3639, 2017.

5) Sato K, Takahashi N, Kato T, Matsuda Y, Yokoji M, Yamada M, Nakajima T, Kondo N, Endo N, Yamamoto R, Noiri Y, Ohno H, Yamazaki K: Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system. Sci. Rep., 7(1): 6955, 2017.

6) Oda M, Domon H, Kurosawa M, Isono T, Maekawa T, Yamaguchi M, Kawabata S, Terao Y: Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. Front. Cell. Infect. Microbiol., 7: Article 300, 2017.

7) Kajikawa T, Meshikhes F, Maekawa T, Hajishengallis E, Hosur KB, Abe T, Moss K, Chavakis T, Hajishengallis G: Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans. J. Clin. Periodontol., 44(5): 472-483, 2017.

8) Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G: Differential expression and roles of secreted frizzled-related protein 5 (Sfrp5) and the wingless homolog Wnt5a in periodontitis. J. Dent. Res., 96(5): 571-577, 2017.

9) Tanasubsinn N, Sittiwangkul R, Pongprot Y, Kawasaki K, Ohazama A, Sastraruji T, Kaewgahya M, Kantaputra PN: TFAP2B mutation and dental anomalies. J. Hum. Genet., 62(8): 769-775, 2017.

10) Suda D, Ohazama A, Maeda T, Kobayashi T: The effect of bone mass and architecture on mandibular condyle after mandibular distraction. Oral Surg. Oral Med. Oral Pathol. Oral Radiol., 124(4): 339-347, 2017.

11) Ida-Yonemochi H, Yamada Y, Yoshikawa H, Seo K: Locally produced BDNF promotes sclerotic change in alveolar bone after nerve injury. PLoS One, 12(1): e0169201, 2017.

12) Yoshikawa H, Yamada Y, Kurose M, Yamamura K, Maeda T, Seo K: Peripheral brain-derived neurotrophic factor modulates regeneration following inferior alveolar nerve injury in rats. J. Oral Facial Pain Headache. 30(4): 346-354, 2016 (published in 2017).

13) 秋葉奈美，長澤麻沙子，小野和宏，前田健康，魚島勝美：新潟大学歯学部における統合型模型実習の取り組み．日歯教誌，33(2): 106-114, 2017．

14) 小田陽平，小野和宏，藤井規孝，小林正治，前田健康：診療参加型歯科臨床実習における web 公開型電子ポートフォリオの開発と運用．日歯教誌，33(2): 65-73, 2017．

15) 藤井規孝，竹中彰治，多部田康一，佐藤直子，秋葉奈美，小田陽平，勝美祐二，小野和宏，前田健康：新潟大学歯学部臨床実習における臨床能力評価．日歯教誌，33(1): 4-11, 2017．

1) Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G: Differential expression and roles of secreted frizzled-related protein 5 (Sfrp5) and the wingless homolog Wnt5a in periodontitis. J. Dent. Res., 2016 in press.

2) Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G.: Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol., 43(3): 238-49, 2016.

3) Domon H, Oda M, Maeawa T, Nagai K, Takeda W, Terao Y: Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. Sci. Rep., 6, Article number: 38013, 2016.

4) Takahashi N, Matsuda Y, Sato K, de Jong PR, Bertin S, Tabeta K, Yamazaki K: Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP. Sci. Rep., 6: 29294, 2016.

5) de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E: ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat. Commun., 17; 7:11551, 2016.

6) Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E: The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut, gutjnl-2015-310710, 2016.

7) Matsuda Y, Kato T, Takahashi N, Nakajima M, Arimatsu K, Minagawa T, Sato K, Ohno H, Yamazaki K: Ligature-induced periodontitis in mice induces elevated levels of circulating IL-6 but shows only weak effects on adipose and liver tissues. J. Periodont. Res., 51(5): 639-46, 2016.

8) Nakajima M, Arimatsu K, Minagawa T, Matsuda Y, Sato K, Takahashi N, Nakajima T, Yamazaki K: Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice. BMC Complement. Altern. Med., 16: 329, 2016.

9) Kawasaki M, Kawasaki K, Oommen S, Blackburn J, Watanabe M, Nagai T, Kitamura A, Maeda T, Liu B, Schmidt-Ullrich R, Akiyama T, Inoue J, Hammond NL, Sharpe PT, Ohazama A: Regional regulation of Filiform tongue papillae development by Ikkα/Irf6. Dev. Dyn., 245(9): 937-946, 2016.

10) Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, Nagai T, Kitamura A, Nishikawa A, Kodama Y, Takagi R, Maeda T, Sharpe PT, Ohazama A: Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr. Patterns, 21(2): 111-118, 2016.

11) Shiino Y, Sakai S, Takeishi R, Hayashi H, Watanabe M, Tsujimura T, Magara J, Ito K, Tsukada T, Inoue M: Effect of body posture on involuntary swallow in healthy volunteers. Physiol. Behav., 155: 250-259, 2016.

12) Uenoyama A, Kakizaki I, Shiomi A, Saito N, Hara Y, Saito T, Ohnuki H, Kato H, Takagi R, Maeda T, Izumi K: Effects of C-xylopyranoside derivative on epithelial regeneration in an in vitro 3D oral mucosa model. Biosci. Biotechnol. Biochem., 80(7): 1344-1355, 2016.

13) Tsujimura T, Tsuji K, Magara J, Sakai S, Suzuki T, Nakamura Y, Nozawa-Inoue K, Inoue M: Differential response properties of peripherally and cortically evoked swallows by electrical stimulation in anesthetized rats. Brain Res. Bull., 122: 12-18, 2016.

14) Nozawa-Inoue K, Harada F, Magara J, Ohazama A, Maeda T: Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint. J. Anat., 228(3): 520-529, 2016.

15) 藤井規孝，竹中彰治，多部田康一，佐藤直子，秋葉奈美，小田陽平，勝美祐二，小野和宏，前田 健康：新潟大学歯学部臨床実習における臨床能力評価とその有用性．日歯教誌 2016 印刷中．

1) Uenoyama A, Kakizaki I, Shiomi A, Saito N, Hara Y, Saito T, Ohnuki H, Kato H, Takagi R, Maeda T, Izumi K: Effects of C-xylopyranoside derivative on epithelial regeneration in an in vitro 3D oral mucosa model. Biosci. Biotechnol. Biochem., 2015 submitted.

2) Maekawa T, Briones AR, Resuello RR, Tuplano JV, Hajishengallis E, Koutsogiannaki S, Lambris JD, Hajishengallis G: Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol., 2015 submitted.

3) Tsujimura T, Tsuji K, Magara J, Sakai S, Suzuki T, Nakamura Y, Nozawa-Inoue K, Inoue M: Differential response properties of peripherally and cortically evoked swallows by electrical stimulation in anesthetized rats. Brain Res. Bull., 2015 submitted.

4) Nozawa-Inoue K, Harada F, Magara J, Ohazama A, Maeda T: Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint. J. Anat., 2015 in press.

5) Shiino Y, Sakai S, Takeishi R, Hayashi H, Watanabe M, Tsujimura T, Magara J, Ito K, Tsukada T, Inoue M: Effect of body posture on involuntary swallow in healthy volunteers. Physiology & Behavior, 2015 in press.

6) Kawasaki K, Kawasaki M, Watanabe M, Eldrus E, Nagai T, Oommen S, Maeda T, Hagiwara N, Que J, Sharpe PT, Ohazama A: Expression of sox genes in tooth development. Int. J. Dev Biol., 59(10-12): 471-478, 2015.

7) Kato H, Marcelo CL, Washington JB, Bingham EL, Feinberg SE: Fabrication of large size ex vivo produced oral mucosal equivalents for clinical application. Tissue Eng. Part C. 21(9): 872-880, 2015.

8) Kato H, Lo A, Kuo S, Nie S, Marcelo CL, Lubman DM, Feinberg SE: Proteomics characterization of primary human oral epithelial cells using a novel culture technique for use in tissue regeneration. MOJ Proteomics Bioinform,. 2(4): 00052, 2015.

9) Maekawa T, Hosur K, Abe T, Kantarci A, Van Dyke TE, Chavakis T, Hajishengallis G: Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. Nature Commun., 6: 8272, 2015.

10) Shin J, Maekawa T, Abe T, Hajishengallis E, Hosur K, Chavakis T, Hajishengallis G: Del-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates. Sci. Transl. Med., 7(307): 307ra155, 2015.

11) Abe T, AlSarhan M, Benakanakere MR, Maekawa T, Kinane DF, Cancro MP, Korostoff JM, Hajishengallis G: The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis. J. Immunol., 195(4): 1427-1435, 2015.

12) Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD: Complement involvement in periodontitis: Molecular mechanisms and rational therapeutic approaches. Adv. Exp. Med. Biol., 865: 57-74, 2015.

13) Maekawa T: Investigation of Wnt5a and Sfrp5 expressions in healthy and chronic periodontitis tissues. Niigata Dent. J., 45(2): 21-28, 2015.

14) Kantaputra PN, Kaewgahya M, Hutsadaloi A, Vogel P, Kawasaki K, Ohazama A, Cairns JRK: GREMLIN 2 mutations and dental anomalies. J. Dent. Res., 94(12): 1646-1652, 2015.

15) Kato H, Izumi K, Uenoyama A, Shiomi A, Kuo S, Feinberg SE: Hypoxia induces undifferentiated phenotype of oral keratinocytes in vitro. Cells Tissues Organs, 199: 393-404, 2014 (published in 2015 April).

16) Shiomi A, Izumi K, Uenoyama A, Saito T, Saito N, Ohnuki H, Kato H, Kanatani M, Nomura S, Egusa H, Maeda T: Cyclic mechanical pressure-loading alters epithelial homeostasis in a three-dimensional in vitro oral mucosa model: Clinical implications for denture-wearers. J. Oral Rehabil., 42(3): 192-201, 2015.

17) Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterková R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Ohazama A: Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium. J. Dent. Res., 94(1): 121-128, 2015.

18) Aida S, Takeishi R, Magara J, Watanabe M, Ito K, Nakamura Y, Tsujimura T, Hayashi H, Inoue M: Peripheral and central control of swallowing initiation in healthy humans. Physiology & Behavior 151: 401-411, 2015.